https://www.kjlewislab.com/scicomm daily 0.75 2024-05-23 https://www.kjlewislab.com/scicomm/exercise-for-bone-health monthly 0.5 2024-05-23 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/2e273a67-24dc-44b8-b3e1-1f812d3ede37/Screenshot+2024-05-23+at+11.48.44%E2%80%AFAM.png Science Communication - Exercise for Bone Health Last, but not least, balance is an underappreciated component of a healthy body and skeleton. Balance keeps us from falling, if you never fall, you probably won’t fracture a bone! Balance allows us to react to uneven surfaces and rapid changes in our environment like a wind gust or a slippery doormat. Core exercises can strengthen your balance, especially things like Bird Dogs, Planks, and Bridges. Meditative activities like yoga and Tai Chi also contribute to balance and mobility. Finally, active balance exercises are easy to add into any workout: step-ups, lunges, and balance boards all support balance training while in motion. https://www.kjlewislab.com/scicomm/nanoparticles-to-study-osteocytes monthly 0.5 2024-05-09 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1778eec8-9faa-4c35-b924-39d006431a79/Screenshot+2024-05-09+at+4.56.41%E2%80%AFPM.png Science Communication - Nanoparticles to Study Osteocytes - Make it stand out An injection of bright nanoparticles allows osteocytes to be visualized inside of bone in their natural environment. https://www.kjlewislab.com/scicomm/microscopy-in-bone monthly 0.5 2024-05-09 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/cb85e571-0628-4d65-b086-a560d218fd91/Microscopy+in+Bone.png Science Communication - Microscopy in Bone - Recent advancements in a powerful type of microscopy, multiphoton microscopy, have allowed cells inside living bone to be visualized deeper with high resolution. This means that fine structures of osteocytes and their neuron-like dendrites, can be seen at depth into a bone! Instead of illuminating an entire cone of the tissue (picture a flashlight beam), multiphoton microscopy sends two beams of individual photons into the tissue at rapid succession (picture two small lasers meeting at a pinpoint). This physics discovery makes opaque tissue like bone accessible for researchers to see into without making large modifications to the tissue environment. https://www.kjlewislab.com/scicomm/osteoporosis monthly 0.5 2024-05-09 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/7d99bf6d-99ce-42a8-823e-feecb09b659f/Healthy+vs+Osteoporotic+Bone.png Science Communication - Osteoporosis - Osteoporosis can be hard to diagnose until a bone breaks, and once the disease is to that point, it is very difficult to treat it. Osteoporotic bone has lower density and fewer osteocytes to sense mechanical stimulation. Most of the available treatments limit the amount of future bone resorption, but they are not able to make weak bone strong again. Recent anabolic, or bone building drugs, have been developed and represent the future of osteoporosis treatment. Healthy bone macrostructure vs osteoporotic bone. https://www.kjlewislab.com/scicomm/bone-cell-types monthly 0.5 2024-05-09 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/4401e79f-da7c-4cb5-9ee0-c86d53459c3a/BoneLiningCell.png Science Communication - Bone Cell types - Honestly the most boring of the bone cells are called bone lining cells. These cells are alive but inactive osteoblasts that cover bone surfaces. They don’t form or break down bone, but they are still connected to the osteocyte network. They do have a role in helping osteoblasts retire into osteocytes, so maybe they can be thought of as the bone AARP agents? But you never know! Up until a few decades ago osteocytes were thought to be simple placeholder cells, so don’t count out bone lining cells yet. https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/76ab5f5e-8157-4e86-bd34-4c7b5e7958fd/Osteocyte.png Science Communication - Bone Cell types - The cell that makes up 90-95% of all bone cells, and the main focus of the Lewis lab, is the osteocyte. Osteocytes are old osteoblasts that retire inside the mineral matrix of bone. They carve a little cave for themselves and then start telling other bone cells what to do for the next 25 years. Osteocytes are the resident mechano-sensors in bone, translating mechanical signals into biochemical messages that direct the actions of other bone cells. In response to exercise (increased tissue deformation), osteocytes signal osteoblasts to activate and form new bone. In response to bedrest (decreased tissue deformation), osteocytes signal osteoclasts to break down excess bone. Considered the conductor within bone, osteocytes can achieve a high level of communication between cell types via their vast interconnected dendritic network, similar to neurons in the brain. But osteocytes are not just signaling cells, they are also able to perform micro-renovations within their individual niches in bone, releasing minerals into the body; with their large population and high surface area, this can have a huge and rapid impact on circulating mineral levels that are normally bound up in the matrix of bone. For this role in mineral homeostasis, osteocytes interact with distant parts of the body such as the kidney, helping to regulate the balance of important minerals like calcium and phosphate. Even with all its roles, the osteocyte story is still unfolding, and research is very much ongoing. Keep an eye out for updates from the Lewis lab! https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/bd745317-4000-4ccc-bb98-9dccce42ab0a/Screen+Shot+2022-11-28+at+8.56.16+AM.png Science Communication - Bone Cell types - Osteoclasts are the cells that break apart bone. They can create small pockets of acid close to the bone surface, dissolving the mineral matrix. This action can be very useful when it is regulated well. Resorption paired with formation allows bone to reorganize its structure, adapting to changing environments like during a growth spurt. Bone resorption can also help provide minerals to the rest of the body if we aren’t getting enough from our diet or need extra during lactation. However, when osteoclasts are not well regulated, and their dissolving of bone outpaces the formation by osteoblasts, you can end up with brittle bones that break easily, like what happens to a lot of people when they reach an advanced age. https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/30208cdd-c0b0-4f3e-af7c-5e16026c293c/Osteoblast.png Science Communication - Bone Cell types - Osteoblasts are the creators of bone. They are actively dividing cells on the surface of bone that secrete the matrix that constitutes the non-living parts of bone. Osteoblasts are polarized, with one side of the cell looking different than the other. You can think of them as an octopus, able to release ink (bone matrix) from their underside when directed. Osteoblasts help to make bone more dense and strong and integrate minerals into the bone matrix for long term storage. https://www.kjlewislab.com/scicomm/mechanotransduction monthly 0.5 2022-11-07 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/df35a277-c450-48c0-a3b5-383de1afae90/Screen+Shot+2022-11-07+at+3.51.16+PM.jpg Science Communication - Mechanotransduction - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kjlewislab.com/home daily 1.0 2024-11-18 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1583006163378-ESUEPAWJ60KII1WCU31M/Projection+of++Project_GC19RR_1.gif https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/e5ac3df5-a6a5-467e-804d-d1d989b9ba72/_V1A7493.jpg Home https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/81f68202-14e8-4642-8a99-d1984dcc8f91/_V1A7310.jpg Home https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/c214a01b-3ccb-491f-8fc5-9103c4265111/_V1A7434.jpg Home https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/a9d73f17-e990-47f5-87f1-7fea69ca369c/IMG_3536.jpg Home https://www.kjlewislab.com/group-members daily 0.75 2025-08-22 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/031f67a7-e4a2-4053-9bf4-99f785239cd3/T018UE6TA95-U05SX10RPQD-65a82d47eba8-512.png Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/82fe5500-2988-42c7-b8a0-29fbdd97d8a7/Hai-+Headshot.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/f4bb9de1-d5af-4811-99bc-457869c2d373/IMG_3554.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/11076fa1-8a3c-4fe5-9db3-f09e59da3c5b/IMG_3500.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/46de9b5a-995c-4057-bf55-f27948a22106/IMG_3503+2.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/8774dcd9-85ff-49af-90ce-c2b46f9a4d02/IMG_3497.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/dba0115e-a4a5-4b4f-94c3-56d262a17989/IMG_3495.jpg Group Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1696442270660-EP3QG48IEWP9ZHV637OX/_V1A7478.jpg Group Members https://www.kjlewislab.com/home-1 daily 0.75 2020-02-29 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1582948564724-B7J276HUOTTY53BHJPZZ/MT3+Loading+Example.gif Home - Welcome to the Lewis Lab We focus on understanding the interplay of mechanical cues and biological changes in musculoskeletal tissues. Specifically, we interrogate how the acute sensing mechanisms in musculoskeletal cells relate to tissue level changes in healthy and disease states. Our investigations in bone are focused on understanding how bone cells interpret mechanical loading in real time using intravital imaging techniques. Additionally, we are interested in understanding how bone interacts with other neighboring tissues in the onset and progression of diseases like osteoarthritis and osteoporosis. https://www.kjlewislab.com/research daily 0.75 2024-10-21 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628293421609-259TH6RPV2MUSN5I379U/unsplash-image-ouyjDk-KdfY.jpg Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628293463435-1QBMAIGE3WXBZB43VV43/osteocyte.png Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628293534947-F22ADI2IWOIERXJK1H5C/microct.png Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628293577244-C1BY8D7YHG6EFHJT2H71/bonehisto.png Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628294077759-OEK8E1YQPO6TIL0ZXZUW/loading.png Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1628294139306-EB2NQ28Q7NOSSJX8B9HL/freq.png Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1632443073670-F7AWEXWM59743NEMD99R/GCaMP+Rapsyn+Mouse3-1.gif Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/419becb7-b9e3-4cfd-871f-71f7bfe51a7b/_V1A7478.jpg Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/7ba304e1-8e11-4749-99b8-c1a7fcbc598f/_V1A7418.jpg Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/99c4a9f9-a12f-44db-999a-a0c7f10714e8/_V1A7349.jpg Research https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/a0713209-5793-45c0-b943-cf70351166cc/IMG_3517+2.jpg Research https://www.kjlewislab.com/publications daily 0.75 2025-08-29 https://www.kjlewislab.com/news-and-events daily 0.75 2025-08-29 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/b3038577-48a2-4baa-a8b9-5511de0d899f/IMG_6131.jpeg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/2a6d1586-6de6-4593-b2d2-82010d1a77eb/IMG_6320.JPG https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/c9b17594-9b68-4b5d-ad76-1252d9a475f5/IMG_7610.jpg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/9508d549-9152-4a92-bb37-6921d7723c7d/IMG_0334.JPG https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/897f5c0a-324f-4c34-bd8f-bfbeaf4da17e/IMG_7606.jpg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/81c50ddf-f456-4165-b369-67e1275daa61/IMG_7615.jpg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/3b402605-d936-425c-bcf9-f5e4a23bdd92/IMG_6199.jpeg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/27904495-9a30-4760-85e8-b47e6261afdc/IMG_0319.jpeg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/c5a63267-8656-4729-8ac7-970a86a123e1/IMG_0328.jpeg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1629480759268-IALRBH8VGWIFDV7NMR0K/IMG_20210820_121517.jpg News and Events - BMES Symposium 2021! Macy Castaneda presenting her poster on fluorescence microscopy in bone https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/c7a09fa2-2636-4260-a3b8-d5379a744170/O%27Matan_Fortin_ChuCarty_Garcia-Ortiz_Kikani_Fukuda_UrreaDeLaPuerta.jpeg News and Events - NSF GRFP 2023 Cornell BME Winners! Congrats to our Andi Garcia-Ortiz https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/660580f0-ae13-42a7-8dc4-3a83f2794a5f/Untitled.png News and Events November 2022 Congratulations to Andi for her recognition as a Dean’s Scholar! Read more here https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1630375207384-1ANJR7KVDWNHGONX9ZVG/20210827_155815.jpg News and Events - BME Immersion Symposium 2021! Check out Samantha Bratcher presenting the work she performed during her clinical immersion this summer in NYC https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/fc0b45d1-dd94-43d0-a1b2-c011dd23ee6b/img_1289.jpeg News and Events March 2023 We so proud and excited for Andi Garcia-Ortiz on being awarded the NSF Graduate Research Fellowship! This will provide her with three years of graduate funding. Congratulations Andi! https://www.kjlewislab.com/contact-us daily 0.75 2024-10-21 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/b1f9654a-5ffb-4cdf-96c1-5cb38c793c8c/_V1A7453.jpg Contact Us https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/03ab8182-1c3a-45f2-91b6-3681ec489463/IMG_3546.jpg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/05a19326-f3e1-4249-b5dd-ece220fbedd0/IMG_3587.jpg https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1eb0a90c-56cb-43d1-8d66-c31f67e430d0/IMG_3525+2.jpg https://www.kjlewislab.com/social daily 0.75 2024-05-10 https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/8c782369-6e93-4651-8fd1-9e74cfef1127/IMG_7570.JPG Social Slope Day (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/f44de2f1-c56a-4c3f-9677-7ea5ad7a6e0d/IMG_7577.jpg Social Slope Day (2024) feat. Flo Rida & A Boogie https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/e3bb0ca0-964e-47f3-b618-e8d7c5dc1637/IMG_6212.jpeg Social Disneyland (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1714677279348-TTEHI31UPG9N52FS43ZP/IMG_6244.jpg Social Star Wars: Galaxy's Edge (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/98295722-30e5-476f-ab1b-3a8e9be138ea/IMG_6896.jpeg Social Dragon Day (2024) feat. Bonassar Lab Members https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/f1e04e48-cc04-4142-bbbe-5d03f819e5dd/IMG_1716+Large.jpeg Social Slope Day feat. Coin (2023) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/2f837ebc-21f6-4ee6-bac5-b648039945f2/IMG_6774.jpeg Social BME Hot Ones (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/fa92bc70-c22f-4c68-aa62-a5a33e04d102/IMG_6459.jpeg Social Melia's 26th Birthday https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/0e5a3b9d-e13a-4220-b190-ff7d7ed76dd7/IMG_7335.jpeg Social Stefaan Verbruggen Ithaca Visit (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/4f2fa1aa-e1b2-4fe3-a5cf-553981e41e69/IMG_6185+2.46.22+PM.jpeg Social ORS Annual Meeting Long Beach, CA (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/a80f91c8-54bb-46f5-9614-d9285739db38/IMG_4033.jpeg Social Annual Lab Photos (2023) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/a93e4964-31ca-4244-8855-9b63808d0e5c/IMG_3717.jpeg Social Melia's A-Exam Celebration (2023) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/5dfdfe08-6865-489f-a3f1-916e30f60ac6/Sam%2C+Andi%2C+Macy+Dairy+Bar+2022.jpg Social Dairy Bar (2023) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/b634ec99-4603-4038-a96c-89a09ed0dc1e/IMG_6835.jpeg Social Painting Party (2024) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/c17c7a90-bade-4745-b846-da9b59a9757a/IMG_0071.jpg Social Canoeing at BeeBee Lake (2023) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/9896d49c-e650-40dd-b0bf-c418c419d1a7/Melia+Art+Gallery+2023.jpeg Social Melia's Art Exhibition @ BRB (2022) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/4bc2c8f8-d740-4a2e-97a1-07ccc20f85d8/IMG_3338.jpeg Social CTLC High Element Ropes Course (2022) https://images.squarespace-cdn.com/content/v1/5e4cafbcea34b0374b3383d9/1696443222336-MPWEP5B600Q6RN2XCONS/IMG_3320.jpg Social CTLC High Element Ropes Course (2022) https://www.kjlewislab.com/education daily 0.75 2024-11-18 https://www.kjlewislab.com/research-videos daily 0.75 2023-02-06 https://www.kjlewislab.com/research-videos/brain-bone-axis monthly 0.5 2023-02-06 https://www.kjlewislab.com/research-videos/c-dots-research monthly 0.5 2023-02-06 https://www.kjlewislab.com/research-videos/mircoct monthly 0.5 2023-02-06 https://www.kjlewislab.com/research-videos/v/cdot-marked-osteocytes monthly 0.5 2023-02-06 https://www.kjlewislab.com/research-videos/v/rgd-functionalized-cdots-over-time monthly 0.5 2023-02-06 https://www.kjlewislab.com/research-videos/v/nonfunctionalized-cdots-over-time monthly 0.5 2023-02-06